Forskning
Vårt ledningsteam arbetar hårt för att ligga i framkant inom området och utveckla de senaste framstegen inom behandlingen.
Vi erbjuder kvinnovänlig behandling som tar hänsyn till kvinnans och barnets hälsa. Vår banbrytande strategi fokuserar på äggkvaliteten, inte på äggkvantiteten.
Forskning
Hardarson T, Hansson C, Lundin K, Hillensjö T, Nilsson L, Stevic J, Reismer E, Borg K, Wikland M, Bergh C
Human Reprod. 2008, 23:2806-12
Hanson C, Hardarson T, Lundin K, Bergh C, Hillensjö T, Stevic J, Westin C, Selleskog U, Rogberg L, Wikland M.
Hum Reprod. 2009 Nov; 24(11):2960-4
Bergh C, Loft A, Lundin K, Ziebe S, Nilsson L, Wikland M, Gröndahl C, Arce JC; CEMAS II Study Group.
Hum Reprod. 2004 ep; 19(9):2109-17.
Cellförändringar i livmoderhalsen
Dr Raghad Samirs avhandling november 2015
Polycystic ovary syndrome: ovarian pathophysiology and consequenses after the menopause
Dr Johanna Schmidts avhandling 2011
Transcription Associated Recombination in Mammalian Cells
Linda Savolainens avhandling 2010
Gene Expression in Mouse Embryonic Stem Cells Deficient in FGFR Signalling and the Identification of the Novel Gene Ened
Renata Gustafsson (Meszaros) avhandling 2008
Studies on the effects of environmental factors on male reproductive function
Dr Nan Birgitte Oldereids avhandling 1999 (länk kommer)
Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study.
Olivennes F, Howles CM, Borini A, Germond M, Trew G, Wikland M, Zegers-Hochschild F, Saunders H, Alam V; CONSORT study group.
Reprod Biomed Online. 2009 Feb; 18(2):195-204
Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization.
Fauser BC, de Jong D, Olivennes F, Wramsby H, Tay C, Itskovitz-Eldor J, van Hooren HG.,
J Clin Endocrinol Metab. 2002 Feb; 87(2):709-1
A prospective, randomized comparison of two starting doses of recombinant FSH in combination with cetrorelix in women undergoing ovarian stimulation for IVF/ICSI.
Wikland M., Bergh C., Borg K., Hillensjö., Howles C.M., Knutsson A., Nilsson L., Wood M.
Human Reprod. 2001, 16:1676-81
High doses of gonadotrophin-releasing hormone antagonist in in-vitro fertilization cycles do not adversely affect the outcome of subsequent freeze-thaw cycles.
Kol S, Lightman A, Hillensjo T, Devroey P, Fauser B, Tarlatzis B, Mannaerts B, ItskovitzEldor J.
Hum. Reprod. 1999 Sep; 14(9):2242-4
IVF/ICSI outcome and serum LH concentration on day 1 of ovarian stimulation with recombinant FSH under pituitary suppression.
Bjercke S, Fedorcsak P, Åbyholm T, Storeng R, Ertzeid G, Oldereid N, Omland A, Tanbo T.
Hum Reprod 20: 2441-7, 2005.
Single blastocyst transfer after ICSI from ejaculate spermatozoa, percutaneous epididymal sperm aspiration (PESA) or testicular sperm extraction (TESE).
Nilsson S, Waldenström U, Engström AB, Hellberg D.
J Assist Reprod Genet. 2007 May; 24(5):167-71
Sperm retrieval, fertilization, and pregnancy outcome in repeated testicular sperm aspiration.
Westlander G, Rosenlund B, Söderlund B, Wood M, Bergh C.
J Assist Reprod Genet. 2001 Mar; 18(3):171-7.
Obstetric outcome of pregnancies following ICSI, classified according to sperm origin and quality.
Wennerholm UB, Bergh C, Hamberger L, Westlander G, Wikland M, Wood M.
Hum Reprod. 2000 May; 15(5):1189-94.
Expression of Bcl-2 family proteins and spontaneous apoptosis in normal human testis.
Oldereid NB, De Angelis P, Wiger R, Clausen OPF.
Molecular Human Reproduction, 7: 403-408, 2001
Micronutrients and male fertility. I: Male Reproductive Dysfunction, ed F.
Oldereid NB. Kandeel,
Informa Healthcare, New York 2007
Induksjon av spermatogenese ved hypogonadotrop hypogonadisme
Oldereid NB, Tanbo TG.
Tidsskr Nor Legefor, 128: 327-9, 2008.
Spermatogenesis and fertility outcome in male hypogonadotrophic hypogonadism.
Oldereid NB, Åbyholm T, Tanbo T.
Human Fertility, 13; 83-89, 2010.
Noninferiority, randomized, controlled trial comparing embryo development using media developed for sequential or undisturbed culture in a time-lapse setup.
Hardarson T, Bungum M, Conaghan J, Meintjes M, Chantilis SJ, Molnar L, Gunnarsson K, Wikland M. Fertil Steril. 2015 Dec;104(6):1452-9.e1-4.
The Alpha Consensus Meeting on the professional status of the clinical embryologist: proceedings of an expert meeting.
Alpha Scientists in Reproductive Medicine. Reprod Biomed Online. 2015 May;30(5):451-61.
Choosing the best embryo by time lapse versus standard morphology.
Kirkegaard K, Ahlström A, Ingerslev HJ, Hardarson T. Fertil Steril. 2015 Feb;103(2):323-32.
No evidence that embryo selection by near-infrared spectroscopy in addition to morphology is able to improve live birth rates: results from an individual patient data meta-analysis.
Vergouw CG, Heymans MW, Hardarson T, Sfontouris IA, Economou KA, Ahlström A, Rogberg L, Lainas TG, Sakkas D, Kieslinger DC, Kostelijk EH, Hompes PG, Schats R, Lambalk CB. Hum Reprod. 2014 Mar;29(3):455-61.
Proteomic analysis of human blastocoel fluid and blastocyst cells.
Jensen PL, Beck HC, Petersen J, Hreinsson J, Wånggren K, Laursen SB, Sørensen PD, Christensen ST, Andersen CY. Stem Cells Dev. 2013 Apr 1;22(7):1126-35.
Prediction of live birth in frozen-thawed single blastocyst transfer cycles by pre-freeze and post-thaw morphology.
Ahlström A, Westin C, Wikland M, Hardarson T. Hum Reprod. 2013 May;28(5):1199-209.
Glycoprotein 130 promotes human blastocyst development in vitro.
Hambiliki F, Hanrieder J, Bergquist J, Hreinsson J, Stavreus-Evers A, Wånggren K. Fertil Steril. 2013 May;99(6):1592-9.
The blastocyst.
Hardarson T, Van Landuyt L, Jones G. Hum Reprod. 2012 Aug;27 Suppl 1:i72-91.
Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: a prospective randomized trial.
Hardarson T, Ahlström A, Rogberg L, Botros L, Hillensjö T, Westlander G, Sakkas D, Wikland M. Hum Reprod. 2012 Jan;27(1):89-96.
Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome.
Seli E, Bruce C, Botros L, Henson M, Roos P, Judge K, Hardarson T, Ahlström A, Harrison P, Henman M, Go K, Acevedo N, Siques J, Tucker M, Sakkas D. J Assist Reprod Genet. 2011 Feb;28(2):137-44.
Trophectoderm morphology: an important parameter for predicting live birth after single blastocyst transfer.
A. Ahlström, C. Westin, E. Reismer, M. Wikland, and T. Hardarson
Human Reproduction, Vol.0, No.0 pp. 1–8, 2011
Non-invasive metabolomic profiling of Day 2 and 5 embryo culture media: a prospective randomized study.
Hardarson T, Ahlström A, Rogberg L, Botros L, Hillensjö T, Westlander G, Sakkas D, Wikland M
Human Reproduction 2011 accepted for publication.
Trophectoderm morphology: an important parameter for predicting live birth after single blastocyst transfer.
Ahlström A, Westin C, Reismer E, Wikland M, Hardarson T.
Hum Reprod. 2011 Dec;26(12):3289-96.
The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting.
Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology.
Hum Reprod. 2011 Jun;26(6):1270-83.
Cross-validation and predictive value of near-infrared spectroscopy algorithms for day-5 blastocyst transfer.
Ahlström A, Wikland M, Rogberg L, Barnett JS, Tucker M, Hardarson T.
Reprod Biomed Online. 2011 May;22(5):477-84.
Low-oxygen compared with high-oxygen atmosphere in blastocyst culture, a prospective randomized study.
Waldenström U, Engström AB, Hellberg D, Nilsson S.
Fertil Steril. 2009 Jun; 91(6):2461-5.
Granulocyte-macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis.
Sjöblom C, Roberts CT, Wikland M, Robertson SA.
Endocrinology. 2005 May; 146(5):2142-53. Epub 2005 Feb 10.
Promising results with 306 single blastocyst transfers.
Nilsson S, Waldenström U, Engström AB, Hellberg D. Fertil Steril. 2005 Jun; 83(6):1849-51.
A randomized, double-blind, controlled trial of the effect of adding follicular fluid meiosis activating sterol in an ethanol formulation to donated human cumulus-enclosed oocytes before fertilization.
Loft A, Bergh C, Ziebe S, Lundin K, Andersen AN, Wikland M, Kim H, Arce JC. Fertil Steril. 2004 Jan; 81(1):42-50.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos.
Sjöblom C, Wikland M, Robertson SA. Biol Reprod. 2002 Dec; 67(6):1817-23.
Laser zona pellucida thinning–an alternative approach to assisted hatching.
Blake DA, Forsberg AS, Johansson BR, Wikland M. Hum Reprod. 2001 Sep; 16(9):1959-64.
A randomized controlled study comparing pain experience between a newly designed needle with a thin tip and a standard needle for oocyte aspiration.
M.Wikland, S. Blad, L. Bungum, T. Hillensjö, P.O. Karlström and S. Nilsson
Human Reproduction, Vol.26, No.6 pp. 1377–1383, 2011
Pre-ovarian block versus paracervical block for oocyte retrieval.
Cerne A, Bergh C, Borg K, Ek I, Gejervall AL, Hillensjö T, Olofsson J, Stener-Victorin E, Wood M, Westlander G
Human Reprod. 2006, 21:2916-21
Electro-acupuncture as a peroperative analgesic method and its effects on implantation rate and neuropeptide Y concentrations in follicular fluid.
Stener-Victorin E, Waldenström U, Wikland M, Nilsson L, Hägglund L, Lundeberg T.
Hum Reprod. 2003 Jul; 18(7):1454-60.
Neonatal and maternal outcome after blastocyst transfer: a population-based registry study.
Ginström Ernstad E, Bergh C, Khatibi A, Källén KB, Westlander G, Nilsson S, Wennerholm UB.
Am J Obstet Gynecol. 2016 Mar;214(3):378.e1-378.e10.
Obstetric outcomes after transfer of vitrified blastocysts.
Wikland M, Hardarson T, Hillensjö T, Westin C, Westlander G, Wood M, Wennerholm UB.
Hum Reprod. 2010 Jul; 25(7):1699-707
Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization.
Thurin A, Hausken J, Hillensjö T, Jablonowska B, Pinborg A, Strandell A, BerghC
N Engl J Med 2004, 351: 2392-402
Emotional adaptation following successful in vitro fertilization.
Hjelmstedt A, Widström AM, Wramsby H, Collins A.
Fertil Steril. 2004 May; 81(5):1254-64.
Patterns of emotional responses to pregnancy, experience of pregnancy and attitudes to parenthood among IVF couples: a longitudinal study.
Hjelmstedt A, Widström A, Wramsby HM, Collins A.
J Psychosom Obstet Gynaecol. 2003 Sep; 24(3):153-62. Erratum in: J Psychosom Obstet Gynaecol. 2003 Dec; 24(4):220
Deliveries and children born after in-vitro fertilisation in Sweden 1982-95: a retrospective cohort study.
Bergh T, Ericson A, Hillensjö T, Nygren K-G, Wennerholm U-B.
Lancet 1999, 354:1579-85.
High pregnancy rates and successful prevention of severe ovarian hyperstimulation syndrome by ‘prolonged coasting’ of very hyperstimulated patients: a multicentre study.
Waldenström U, Kahn J, Marsk L, Nilsson S.
Hum Reprod. 1999 Feb; 14(2):294-7.
Medfødte misdannelser hos barn født etter assistert befruktning i Norge.
Oldereid NB, Tanbo T, Irgens LM, Engelund IE, Åbyholm T.
Tidsskr Nor Lægeforen, 123:2696-9, 2003
Pregnancy outcome according to male diagnosis following ICSI with non-ejaculated sperm compared with ejaculated sperm controls.
Oldereid NB, Hanevik HI, Bakkevig I, Romundstad LB, Magnus Ø, Hazekamp J, Hentemann M, Eikeland S, Skrede S, Reitan I, Tanbo TG.
RBM Online, 29: 417-423, 2014.
Risk of Cancer in Children Conceived by Assisted Reproductive Technology.
Reigstad M.M., Larsen I.K., Myklebust T.Å., Robsahm T.E., Oldereid N.B., Brinton L.A., Storeng R.
Pediatrics, 137:1-12, 2016.
Obstetric and neonatal complications in pregnancies conceived after oocyte donation – a systematic review and meta-analyses.
Storgaard M, Loft A, Bergh C, Wennerholm UB, Söderström-Anttila V, Romundstad LB, Aittomaki K, Oldereid NB, Forman J, Pinborg A.
BJOG, 124:561-572, 2017.
Literature review on cancer risk in children born after fertility treatment suggests increased risk of haematological cancers.
Reigstad MM, Oldereid NB, Omland AK, Storeng R.
Acta Paediatrica, 106: 698-709, 2017.
The effect of paternal factors on perinatal and paediatric outcomes- a systematic review and meta-analysis
.Oldereid NB, Wennerholm U-B, Pinborg A, Loft A, Laivuori H, Petzold M, Romundstad LB, Söderström-Anttila V, Bergh C.
Human Reproduction Update, publisert 2018 Febr 15.
Access to artificial reproduction technology in the Nordic countries in 2004.
Sol Olafsdottir H, Wikland M, Möller A.
Acta Obstet Gynecol Scand. 2009; 88(3):301-7.
Economic evaluation of infertility treatment for tubal disease.
Granberg M, Strandell A, Thorburn J, Daya S, Wikland M.
J Assist Reprod Genet. 2003 Aug; 20(8):301-8.
Analysis of the cost effectiveness of recombinant versus urinary follicle-stimulating hormone in in vitro fertilization/intracytoplasmic sperm injection programs in the United States.
Silverberg K, Daya S, Auray JP, Duru G, Ledger W, Wikland M, Bouzayen R, O’Brien M, Falk B, Beresniak A.
Fertil Steril. 2002 Jan; 77(1):107-13.
Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy.
Rodriguez-Wallberg KA, Karlström PO, Rezapour M, Castellanos E, Hreinsson J, Rasmussen C, Sheikhi M, Ouvrier B, Bozóky B, Olofsson JI, Lundqvist M, Hovatta O.
Acta Obstet Gynecol Scand. 2015 Mar;94(3):324-8.
The educational and professional status of clinical embryology and clinical embryologists in Europe.
Kovačič B, Plas C, Woodward BJ, Verheyen G, Prados FJ, Hreinsson J, De los Santos MJ, Magli MC, Lundin K, Plancha CE.
Hum Reprod. 2015 Aug;30(8):1755-62
Transplantation of human embryonic stem cells onto a partially wounded human cornea in vitro.
Hanson C, Hardarson T, Ellerström C, Nordberg M, Caisander G, Rao M, Hyllner J, Stenevi U.
Acta Ophthalmol. 2013 Mar;91(2):127-30.
N-glycans of human protein C inhibitor: tissue-specific expression and function.
Sun W, Grassi P, Engström A, Sooriyaarachchi S, Ubhayasekera W, Hreinsson J, Wånggren K, Clark GF, Dell A, Schedin-Weiss S.
PLoS One. 2011;6(12):e29011.
Prostasomal DNA characterization and transfer into human sperm.
Ronquist GK, Larsson A, Ronquist G, Isaksson A, Hreinsson J, Carlsson L, Stavreus-Evers A.
Mol Reprod Dev. 2011 Jul;78(7):467-76.
Vitrification versus controlled-rate freezing in cryopreservation of human ovarian tissue.
Keros V, Xella S, Hultenby K, Pettersson K, Sheikhi M, Volpe A, Hreinsson J, Hovatta O.
Hum Reprod. 2009 Jul;24(7):1670-83.
Tumour incidence in Swedish women who gave birth following IVF treatment.
Kristiansson P, Björ O, Wramsby H.
Hum Reprod. 2007 Feb; 22(2):421-6.
Detection of Tc-99m labelled albumin particles in the Fallopian tubes after intraperitoneal deposition.
Lundberg S, Wånggren K, Almström H, Lundberg HJ, Asard PE, Wramsby H.
Eur J Obstet Gynecol Reprod Biol. 2005 Apr 1; 119(2):210-4.
Low-dose aspirin in a short regimen as standard treatment in in vitro fertilization: a randomized, prospective study.
Waldenström U, Hellberg D, Nilsson S.
Fertil Steril. 2004 Jun; 81(6):1560-4.
Human blastocysts for the development of embryonic stem cells.
Sjögren A, Hardarson T, Andersson K, Caisander G, Lundquist M, Wikland M, Semb H, Hamberger L.
Reprod Biomed Online. 2004 Sep; 9(3):326-9.
Radioactivity in cervical mucus after intraperitoneal deposition of Tc-99m labelled albumin particles before and after sterilisation.
Wånggren K, Lundberg S, Lundberg HJ, Asard PE, Wramsby H.
Eur J Obstet Gynecol Reprod Biol. 2003 Jun 10; 108(2):203-8.
The application of quality systems in ART programs.
Wikland M, Sjöblom C.
Mol Cell Endocrinol. 2000 Aug 15; 166(1):3-7.
Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility.
Omland AK, Abyholm T, Fedorcsak P, Ertzeid G, Oldereid NB, Bjercke S, Tanbo T.
Human Reprod, 2004.
Intracytoplasmic sperm injection (ICSI) in unexplained and stage I endometriosis-associated infertility after fertilization failure with in vitro fertilization (IVF).
Omland AK, Bjercke S, Ertzeid G, Fedorcsak P, Oldereid NB, Storeng R, Åbyholm T, Tanbo T. J
Assist Reprod Genet 23:351-7, 2006.
In vitro fertilization is a successful treatment in endometriosis-associated infertility.
Opøien HK, Fedorcsak P, Omland AK, Åbyholm T, Bjercke S, Ertzeid G, Oldereid N, Mellembakken J, Tanbo T.
Fertil Steril 2012
Ovarialfunksjon og fertilitet etter kryopreservering av ovarialvev ved kreftbehandling.
Smaavik-Johansen, Tanbo T, Oldereid NB.
Godkjent for publisering Tidsskrift for den norske legeforeningen, 2018.Infertilitetsbehandling og kreftrisiko.
Storeng R, Omland AK, Vangen S, Oldereid NB.
Tidsskrift Nor Legefor, 22: 2494-9, 2012.
Risk of breast cancer following fertility treatment – A registry based cohort study of parous women in Norway.
Reigstad M.M., Larsen I.K., Myklebust T.Å., Robsahm T.E., Oldereid N.B., Omland A.K., Vangen S., Brinton L.A., Storeng R.
Int J Cancer, 136: 1140-8, 2015.
Cancer Risk in Parous Women Treated with Assisted Reproductive Technology (ART) in Norway.
Reigstad M.M., Larsen I.K., Myklebust T.Å., Robsahm T.E., Oldereid N.B., Omland A.K., Vangen S., Brinton L.A., Storeng R.
Human Reproduction, 30: 1952-1963, 2015.
The Nordic Health Registries – an important part of modern medical research.
Reigstad M.M., Larsen I.K., Myklebust T.Å., Robsahm T.E., Oldereid N.B., Storeng R.
Letter to Editor i Human Reproduction. 31: 216-217, 2016.
Assisted reproductive technology and severe postpartum hemorrhage: A case-control study.
Nyfløt LT, Sandven I, Oldereid NB, Stray-Pedersen B, Vangen S.
BJOG, 124:1198-1205, 2017.
Cancer Risk in Women Treated with Fertility Drugs According to Parity status – a Registry-based Cohort Study.
Reigstad MM, Storeng R, Myklebust TÅ, NB Oldereid, AK Omland, Robsahm TE, Brinton LA, S Vangen, Larsen IK.
Cancer Epidemiology Biomarkers & Prevention, 26: 953-962, 2017.