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 Key Terms and Definitions in IVF and Assisted Reproduction

Glossary

A
AID (Artificial Insemination of Donor sperm)

Insemination with donated sperm.

AIH (Artificial Insemination of Husband's sperm)

Partner insemination, which may be a suitable treatment if the couple has difficulty having intercourse.

AMH (Anti-Müllerian Hormone)

A hormone produced by the small, growing follicles in the ovaries. The level of AMH in the blood reflects the number of remaining eggs in the ovaries (see Ovarian Reserve). Younger women typically have more eggs and thus higher AMH. An important parameter in fertility assessment and treatment planning.

Antagonist cycle

In the short protocol, the ovaries are stimulated without prior downregulation. Hormone treatment starts with menstruation, and a few days into treatment, a medication (GnRH antagonist) is given to regulate the body's ovulation signal.

Assisted reproduction

A collective term for various methods used to bring together sperm and egg to help a couple have a child. Either only sperm are handled outside the body (see Insemination), or both eggs and sperm are treated outside the body (see IVF, ICSI).

Azoospermia (absence of sperm in semen)

Caused by impaired sperm production in the testicle or a blockage in the epididymis/vas deferens.

B
Blastocyst culture

In long-term culture, embryos are allowed to grow for 5-6 days before transfer, reaching the blastocyst stage and containing 150-200 cells.

C
Cervix

Cervix uteri.

Coitus

Sexual intercourse.

Corpus luteum (yellow body)

The transformed follicle after ovulation.

D
Double donation

Can be offered to couples or single women. Both donated eggs and donated sperm are used for treatment. Eggs may be fresh or frozen, while sperm are always frozen.

E
Ejaculate

Semen.

Embryo

A fertilized egg that has begun to divide.

Embryo donation

Donation of surplus embryos from IVF treatment that have been frozen. If the couple does not wish to have more children, they may offer their embryos to others. Not yet offered in Sweden due to lack of complete ethical guidelines.

Endometriosis

Endometrial tissue outside the uterine cavity.

Endometrium

Uterine lining.

Epididymis

The epididymis is a long, coiled tube located on the back of each testicle in the male reproductive system.

Egg donation

If the woman's infertility is due to few or no eggs, or poor egg quality, the couple can become parents through egg donation. Donated eggs are fertilized with the partner's sperm, and an embryo is transferred to the woman's uterus.

ET (Embryo Transfer)

After IVF, the embryo (a fertilized and divided egg) is transferred. The doctor inserts a thin guide into the cervical canal and monitors placement via ultrasound. The embryologist draws the embryo into a thin catheter, which is inserted into the uterus.

F
Follicle

Ovarian follicle.

Freeze storage

If several eggs are fertilized and develop normally during IVF, surplus embryos of good quality can be frozen. If the woman does not become pregnant with the fresh embryo, a frozen embryo can be thawed and transferred. By law, embryos may be stored for up to 10 years.

Freezing technique

Two main freezing techniques: slow freezing (used for day 2/3 embryos) and vitrification (rapid freezing, used for blastocysts). Each embryo is stored in ID-labeled straws in liquid nitrogen tanks.

FSH (Follicle Stimulating Hormone)

Stimulates follicle growth.

G
Gamete

Sex cell, either egg or sperm.

Gonadotropin

Collective name for pituitary hormones FSH and LH.

H
hCG (Human Chorionic Gonadotropin)

Pregnancy hormone.

Hormone stimulation

In cases of ovulation disorders, ovulation can be induced with tablets or injections. Ultrasound and hormone tests are used to guide treatment.

I
ICSI (Intracytoplasmic Sperm Injection)

If the man's sperm sample contains too few or poorly motile sperm, a single sperm is injected into each mature egg during IVF. Used in over half of IVF treatments.

Implantation

An embryo attaches to the uterine lining.

Intra-couple donation

Sometimes called embryo donation, embryo adoption, or partner treatment. Offered to same-sex couples (or trans man-trans man/woman) where eggs are aspirated from one and transferred to the other. Treatment uses fresh eggs or frozen embryos.

IVF (In Vitro Fertilization)

Test-tube fertilization, used for all forms of involuntary childlessness: female, male, unexplained infertility, and for egg/sperm donation.

J
K
L
LH (Luteinizing Hormone)

Induces ovulation.

Luteal phase

The period after ovulation or embryo transfer.

M
Micro-TESE (Microscopic Testicular Sperm Extraction)

In some cases, small surgical biopsies are taken from the testicle to increase the chance of finding sperm. Also performed under local anesthesia.

Myoma

Fibroids in the uterus.

N
O
OHSS (Ovarian Hyperstimulation Syndrome)

Overstimulation occurs in 1-2% of IVF cases. Hormone doses cause too many follicles to grow, leading to abdominal swelling, pain, and breathing difficulty. Symptoms usually appear after embryo transfer. Treatment varies by severity; rest and monitoring are often sufficient, but hospital care may be needed. Increased risk of blood clots; anticoagulant treatment may be necessary. Pregnancy is not negatively affected. With shorter hormone stimulation (antagonist protocol), OHSS risk has decreased significantly. All embryos can be frozen, and transfer postponed to a later cycle with no risk to the woman and equal pregnancy chances.

OPU (Ovum Pick-Up)

Aspiration of eggs (egg retrieval) from the ovaries via the vagina.

Ovarian reserve (see AMH)

The number of remaining eggs in the ovaries at a given time. Good ovarian reserve increases the chances of having a child with IVF.

Ovary

Ovary.

Ovulation

Release of an egg from the ovary.

P
PESA (Percutaneous Epididymal Sperm Aspiration)

If sperm are absent in semen due to a blockage (e.g., after infection or sterilization), sperm can be retrieved from the epididymis under local anesthesia.

Progesterone

Hormone produced by the corpus luteum that makes the uterine lining more receptive to the embryo.

Q
R
S
Sperm donation

If the man lacks sperm, the couple can become parents through sperm donation. The woman's eggs are fertilized with donated sperm, and an embryo is transferred to her uterus. Also available to lesbian couples.

Standard IVF (St.IVF)

Sperm and eggs are placed together in a dish with nutrient solution, allowing sperm to fertilize eggs "naturally."

T
TESA (Testicular Sperm Aspiration)

If sperm are absent in semen, sperm can be retrieved directly from the testicle via needle biopsy under local anesthesia.

Testis

Testicle.

Testosterone

Male sex hormone.

Tuba uterina

Fallopian tube.

U
Uterus

Uterus.

V
Vitrification

A rapid two-step process for freezing eggs or embryos. First, dehydration removes water from cells, then the cells are instantly transformed from liquid to solid, preventing harmful ice crystals.

W
Workup (Assessment)

To determine why pregnancy is delayed, the couple meets with a doctor for consultation and examinations.

X
Y
Z